The high levels of insulin and insulin-resistance that accompany diabetes are often associated with fatty liver or hepatic steatosis, an untreatable condition that can lead to chronic liver disease and death. In this condition, large lipid-filled compartments accumulate in the cells of the liver due to an increase in production of fatty acids in the liver. The end result is an enlarged liver.

Following up research that indicated that eating soy protein reduces lipid production and prevents hyperinsulinemia (the loss of effectiveness of insulin), Dr. Nimbe Torres, of the Instituto Nacional de Ciencias Medicas y Nutricion in Mexico, investigated the effects of a diet high in soy protein on the development of fatty liver associated with diabetes.

Dr. Torres fed Zucker diabetic fatty rats that develop hyperinsulinemia and hepatic steatosis a diet of soy protein for 160 days. She found that the consumption of soy protein prevented the accumulation of triglycerides and cholesterol in the liver despite the development of obesity and hyperinsulinemia in the rats.

"We also observed that the effects of soy protein were due to a low expression of genes involved in the synthesis of fatty acids and triglycerides in the liver," explained Dr. Torres. "These changes were due to a reduction in the transcription factors that control the expression of genes involved in lipid production."

In addition, levels of a transcription factor involved in controlling genes involved in fatty acid breakdown, as well as its target genes, were increased in rats fed soy protein. Thus, feeding rats a soy-rich diet reduced the amount of fatty acid in their liver by not only reducing lipid production but also by increasing its breakdown.

Although further research is needed, Dr. Torres believes that consuming soy protein could very well reduce insulin resistance, renal damage, and fatty liver, improving quality of life.

asbmb/

FBI funds designated for investigating fraud in health care also seem to have shifted to other purposes, including fighting terrorism, and military funds for cleaning up polluted sites and meeting clean air standards have been proposed for capping and exemption by the Pentagon.

These observations are not intended to diminish the tragedies of 11 September 2001 or 7 July 2005 or other terrorist actions, nor to negate the importance of developing effective ways of making sure such tragedies are not repeated, says the author.

It is certainly justifiable for governments to appropriate substantial funds to prevent potential future threats to our security. But public funding for current threats should not be compromised.

"Predictable tragedies happen every day. We know strategies to reduce deaths from tobacco, alcohol, poor diet, unintentional injuries, and other predictable causes. And we know that millions of people will die unless we protect the population against these routine causes of death," she concludes.

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